Born in Benevento, Maria Laura De Sciscio obtained her BS in Chemistry from Sapienza University of Rome and her MS in Chemistry (Bio-organics) from Alma Mater Studiorum - University of Bologna. She is currently a PhD candidate in Chemical Sciences at Sapienza University of Rome, specializing in the theoretical-computational modeling of protein structure and dynamics. In particular, her research focuses on the comprehensive characterization of spontaneous post-translational modifications and their impact on biotherapeutics stability. As part of her PhD, she was a visiting PhD student at the University College of London, where she applied integrative modeling approaches to the study of antibody dynamics.

Courses Taught
General Chemistry I LAB - CHEM1033

Pubblications
Tuning Antibody Stability and Function by Rational Designs of Framework Mutations. ⋄ J. C. F. Ng, A. Chenoweth, M. L. De Sciscio, M. Grandits, A. Cheung, T. Chu, A. McCraw, J. Chauhan, Y. Liu, D. Guo, S. Patel, A. Kosmider, D. Iancu, S. N. Karagiannis, and F. Fraternali. 03/2025

Dissecting Methionine Oxidation by Hydrogen Peroxide in Proteins: Thermodynamics, Kinetics, and Susceptibility Descriptors. ⋄ M. L. De Sciscio, F. Centola, S. Saporiti, and M. D’Abramo. J. Chem. Inf. Model. 65(2), 749-761 01/2025

Corylus Avellana Non-Specific Lipid-Transfer Protein Cor a 8 Is a Moonlighting Enzyme with a New Lipase Activity. ⋄ A. Fissore, G. Di Napoli, M. L. De Sciscio, V. Santoro, E. Salladini, M. Marengo, S. Oliaro-Bosso, G. Vanzetti, A. Caratti, F. Dal Piaz, F. Piazza, M. Manzoli, G. Genova, A. G. Barbiroli, S. Iametti, F. Fraternali, and S. Adinolfi. 11/2024

Binding of Steroid Substrates Reveals the Key to the Productive Transition of the Cytochrome P450 OleP. ⋄ A. Costanzo, F. Fata, I. Freda, M. L. De Sciscio, E. Gugole, G. Bulfaro, M. Di Renzo, L. Barbizzi, C. Exertier, G. Parisi, M. D’Abramo, B. Vallone, C. Savino, and L. C. Montemiglio. Structure 32(9), Elsevier, 1465–1476.e3. 09/2024

Conformational and Dynamic Properties of the KH1 Domain of FMRP and Its Fragile X Syndrome Linked G266E Variant. ⋄ F. Catalano, D. Santorelli, A. Astegno, F. Favretto, M. D’Abramo, A. Del Giudice, M. L. De Sciscio, F. Troilo, G. Giardina, A. Di Matteo, and C. Travaglini-Allocatelli. Biochim. Biophys. Acta - Proteins and Proteomics 1872(4), p.141019. 07/2024

A Finely Balanced Order–Disorder Equilibrium Sculpts the Folding–Binding Landscape of an Antibiotic Sequestering Protein. ⋄ L. Natarajan, M. L. De Sciscio, A. N. Nardi, A. Sekhar, A. Del Giudice, M. D’Abramo, and A. N. Naganathan. Proc. Natl. Acad. Sci. 121(20), e2318855121. 05/2024

Modelling the Assembly and Flexibility of Antibody Structures.⋄ D. Guo, M. L. De Sciscio, J. C. F. Ng, and F. Fraternali. Curr. Opin. Struct. Biol. 84, p. 102757. 02/2024

Molecular Modeling of the Deamidation Reaction in Solution: A Theoretical–Computational Study. ⋄ M. L. De Sciscio, A. N. Nardi, F. Centola, M. Rossi, E. Guarnera, and M. D’Abramo. J. Phys. Chem. B 127(44), American Chemical Society, pp. 9550–9559. 11/2023

Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP. 01/2023 ⋄ M. L. De Sciscio, A. N. Nardi, G. Parisi, G. Bulfaro, A. Costanzo, E. Gugole, C. Exertier, I. Freda, C. Savino, B. Vallone, L. C. Montemiglio, and M. D’Abramo. Molecules 28(2), p. 832.

Theoretical Evaluation of Sulfur-Based Reactions as a Model for Biological Antioxidant Defense. 01/2022 ⋄ M. L. De Sciscio, V. D’Annibale, and M. D’Abramo. Int. J. Mol. Sci. 23(23), p. 14515.

In Silico and In Vitro Analysis of Major Cannabis-Derived Compounds as Fatty Acid Amide Hydrolase Inhibitors. ⋄ E. Criscuolo, M. L. De Sciscio, F. Fezza, and M. Maccarrone. Molecules 26(1), p. 48. 01/2021

Exploring the Role of L10 Loop in New Delhi Metallo–Lactamase (NDM-1): Kinetic and Dynamic Studies. ⋄ A. Piccirilli, E. Criscuolo, F. Brisdelli, P. S. Mercuri, S. Cherubini, M. L. De Sciscio, M. Maccarrone, M. Galleni, G. Amicosante, and M. Perilli. Molecules 26(18), p. 5489. 01/2021

Additional Information
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